Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis
نویسندگان
چکیده
منابع مشابه
Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis
The identification of mutations that enhance antibody affinity while maintaining high antibody specificity and stability is a time-consuming and laborious process. Here, we report an efficient methodology for systematically and rapidly enhancing the affinity of antibody variable domains while maximizing specificity and stability using novel synthetic antibody libraries. Our approach first uses ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2017
ISSN: 1664-3224
DOI: 10.3389/fimmu.2017.00986